top of page

Publications

In situ molecular architecture of the mammalian sperm nuclear vacuole

Braxton, J. R., Qu, S., Skinner, W. M., Shiozaki, M., Jean, N., Yan, R., Zhao, X., Yu, Z., Lishko, P. V., Chen, Z.

Biorxiv (2026).​​​​​​​​​​​​​​​​

Image 5-24-26 at 7.15 PM.png

Automated assembly of protein complexes from cryo-EM maps with structure-informed Monte Carlo Tree Search

Dilip, R.*, Qu, S. J.*, Chen, Z. ^, Van Valen, D. A ^ (* equal contribution, ^ co-corresponding authors).

Biorxiv (2026).​​​​​​​​​​​​​​​​

Figure2.png

​In situ cryo-electron tomography reveals the asymmetric architecture of mammalian sperm axonemes

Chen, Z., Greenan, G. A., Shiozaki, M., Liu, Y., Skinner, W., Zhao, X., Zhao, S., Yan, R., Guo, C., Yu, Z., Lishko, P. V., Agard, D. A. & Vale, R. D.

Nat. Struct. Mol. Biol. 30, 360-369 (2023).

De novo protein identification in mammalian sperm using high-resolution in situ cryo-electron tomography

Chen, Z. ^Shiozaki, M., Haas, K., Skinner, W. M., Zhao, S., Guo, C., Polacco, B. J., Yu, Z., Krogan, N. J., Lishko, P. V., Kaake, R., Vale, R. D.^ & Agard, D. A.^ (^ co-corresponding authors)

Cell 186, 5041-5053 (2023).

​

​

​

​

​

​

​

​

​

​

​

​

​

​

​

​

​​

Graphic abstract.png
Asymmetries3.png
AreTomo.png
Mdn1_C18.png

​​

AreTomo: An integrated software package for automated marker-free, motion-corrected cryo-electron tomographic alignment and reconstruction

Zheng, S., Wolff, G., Greenan, G. A., Chen, Z., Faas, F. G. A., Bárcena, M., Koster, A. J., Cheng, Y. & Agard, D. A.

J. Struct. Biol. 6, 100068 (2022).

​

​

​​

​​​​​​​​

Structural insights into Mdn1, an essential AAA protein required for ribosome biogenesis

Chen, Z., Suzuki, H., Kobayashi, Y., Wang, A. C., Dimaio, F., Kawashima, S. A., Walz, T., Kapoor, T. M.

Cell 175, 822-834 (2018).

​

​

​​

Graphical Abstract_Kapoor082616_edited.j

​​​​​​Potent, reversible and specific chemical inhibitors of eukaryotic ribosome biogenesis

Kawashima, S. A.*, Chen, Z.*, Aoi, Y., Patgiri, A., Kobayashi, Y., Nurse, P. & Kapoor, T. M. (* equal contributions)

Cell 167, 512-524 (2016)​​​​.​

JACS12.png

​​​​​​​​​​Catalytic protein modification with dirhodium metallopeptides: specificity in designed and natural systems

Chen, Z., Vohidov, F., Coughlin, J. M., Stagg, L. J., Arold, S. T., Ladbury, J. E. & Ball, Z. T.

J. Am. Chem. Soc. 134, 10138-10145 (2012).

​​

 

 

 

​

​Site-specific protein modification with a dirhodium metallopeptide catalyst

Chen, Z., Popp, B. V., Bovet, C. L. & Ball, Z. T.

ACS Chem. Biol. 6, 920-925 (2011)​.

ACSCB11-selective modification.png
APL09_final.png
CC12-site-specific inhibition.png

Nanofluidic electrokinetics in nanoparticle crystal

Chen, Z., Wang, Y., Wang, W. & Li, Z.

Appl. Phys. Lett. 95, 102105 (2009).​

​Sequence-specific inhibition of a designed metallopeptide catalyst

Popp, B. V., Chen, Z. & Ball, Z. T.

Chem. Commun. 48, 7492-7494 (2012).​

Microfluidic patterning of nanoparticle monolayer

Chen, Z., Zhao, Y.; Wang, W. & Li, Z.

Microfluidics and Nanofluidics 7, 585-591 (2009).

©2024 by Chen Lab at Caltech

bottom of page