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Structural Cell Biology of Development

We focused on in situ assembly and functions of macromolecular complexes in developmental biology.

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Developmental Biology at the Near-Atomic Resolution
We combine chemical biology, biochemistry and structural biology approaches to study developmental biology at near-atomic resolution in situ.

Cryo-Electron Tomography
We draw inspiration from cell biology and AI-assisted modeling to tackle previously inaccessible problems.

Biophysics of Cilia
We study the fundamental molecular mechanisms and engineering principles of ciliary motions. 

New Directions
We are excited to seize any opportunities if pushing the boundaries of in situ cryoET would make a difference in any biological questions.

See
Publications for more.

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2024 Jul: Julian was awarded the Jane Coffin Childs Postdoctoral Fellowship! Congrats!
2024 Mar
: Julian was awarded the Caltech Presidential Postdoctoral Fellowship! Congrats!
2024 Mar
: We just got funding support from the Shurl and Kay Curci Foundation for our new adventures!
2024 Feb: we just got funding support from the Caltech Center for Evolutionary Science.
2024 Jan: we just got funding support from the Merkin Institute to develop AlphaFold2-assisted modeling.

2023 Dec: Zhen started at Caltech officially!
2023 Oct: Julian and Zhen started at Caltech as a postdoctoral fellow and a visiting associate.

©2024 by Chen Lab at Caltech

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